The 624th Aerospace Medicine Flight, located at Andersen Air Force Base, Guam, provides medical support to Air Force Reserve organizations to ensure wartime readiness. The unit provides physical exams and immunizations to units in Guam and can activate an Aeromedical Staging Facility in place or in a deployed location.

Peacetime: Train personnel to ensure full wartime mission capability; provide physical exams and immunizations to 624 RSG units in Guam.

Wartime: Activate and staff a Contingency Aeromedical Staging Facility in deployed locations and/or deploy a Critical Care Air Transport Team in support of Air Mobility Command.

The 624th Aerospace Medicine Flight officially stood up on Nov. 1, 2011. Headquarters Air Force Reserve Command formed the 624th AMDS from the 724th Aeromedical Staging Flight, which had been assigned to the 624th Regional Support Group. The 724th Aeromedical Staging Flight was inactivated on Nov. 1, 2011, then reactivated as the 624th Aerospace Medicine Squadron, and subsequently the 624th Aerospace Medicine Flight.